Library Catalogue

Amazon cover image
Image from Amazon.com
Image from Google Jackets

Introduction to cancer metastasis / edited by Aamir Ahmad

Contributor(s): Material type: TextTextSeries: Cancer metastasis (2017) ; v. 1.Publication details: Amsterdam: Academic Press / Elsevier, c2017Description: xii, 403 pages : illustrations (some color) ; 24 cmISBN:
  • 9780128040034
  • 0128040033
Subject(s): DDC classification:
  • 362.19699/4 23
LOC classification:
  • RC269.5.I58 2017
NLM classification:
  • 2017 C-488
  • QZ 203
Contents:
List of contributors -- Preface -- I CANCER METASTASIS FROM PRIMARY ORGANS -- 1 CANCER METASTASIS: AN INTRODUCTION -- 1. Introduction -- 2. Disruption of Cell Adhesion: Initiation of Metastasis -- 3. Matrix Metalloproteinases in Cancer Metastasis -- 4. EMT in Cancer Metastasis -- 5. Organ-Specific Metastasis -- 6. microRNAs and Cancer Stem Cells in Cancer Metastasis -- 7. Conclusions and Perspectives -- 2. BREAST CANCER METASTASIS -- 1. Introduction -- 2. Biology -- 3. Metastatic Dissemination -- 4. Prognostic Factors After Recurrence -- 5. Treatment for Metastatic Breast Cancer -- 6. Conclusions -- 3. PROSTATE CANCER METASTASIS - 1. Epidemiology and Overview of Metastatic Prostate Cancer -- 2. Cellular Biology of Prostate Cancer Metastases -- 3. The Metastatic Cascade -- 4. Conclusions -- 4. LUNG CANCER METASTASIS -- 1. General Information -- 2. Mechanism of Metastasis -- 3. Molecular Mechanism in the Regulation of Lung Cancer Metastasis -- 4. Epithelial to Mesenchymal Transition in Lung Cancer -- 5. Cancer Stem Cells -- 6. Concluding Remarks -- 5. CERVICAL CANCER METASTASIS -- 1. Introduction -- 2. Risk Factors -- 3. Pathogenesis -- 4. Histopathology -- 5. Routes of Dissemination -- 6. Major Molecular Factors -- 7. Conclusion -- 6. COLORECTAL CANCER METASTASIS -- 1. Introduction -- 2. Molecular Aspects of Colorectal Cancer Metastasis -- 3. Main Sites of Colorectal Cancer Metastasis -- 4. Therapeutic Options for Metastatic Colorectal Cancer -- 5. Challenges and Probable Solutions -- 6. Conclusions -- 7. METASTATIC PANCREATIC CANCER: CURRENT STATE AND FUTURE DIRECTIONS -- 1 Introduction -- 2 Management of pancreatic ductal adenocarcinoma -- 3 Molecular mechanisms driving metastasis -- 4 In vivo experimental models -- 5 Open question: onset and dynamics of metastasis -- 6 Conclusions -- 8 GASTRIC CANCER METASTASIS -- 1 Epidemiology and screening programs -- 2 Metastatic GC -- clinical aspects -- 3 Diagnosis of metastatic GC with a particular focus on 18-F-FDG PET/CT -- 4 Prognostic and predictive factors -- 5 Biomarkers -- 6 Treatment methods of metastatic GC -- 7 Conclusion -- 9 HEPATOCELLULAR CARCINOMA: METASTATIC DISEASE -- 1 Introduction -- 2 Epidemiology -- 3 Diagnosis -- 4 Prognosis and staging -- 5 Treatment -- 6 Conclusions -- 10 METASTATIC BLADDER CANCER -- 1 Introduction -- 2 Epidemiology -- 3 Staging -- 4 Grading -- 5 Staging tools -- 6 Emerging biomarkers -- 7 Prognostic factors -- 8 Clinical presentation of metastatic bladder disease -- 9 Management of clinically localized bladder cancer, positive pelvic nodes and metastatic disease -- 10 Clinical prognosticators -- 11 Management of metastatic bladder cancer -- 12 New agents -- 13 Immunotherapy -- 14 Role of surgery in metastatic bladder cancer -- 15 Conclusions -- 11 METASTATIC CUTANEOUS SQUAMOUS CELL CARCINOMAS -- 1 Introduction -- 2 Defining the high-risk variant -- 3 Staging systems -- 4 Treating high-risk cutaneous squamous cell carcinoma -- 5 Sentinel node biopsy -- 6 Treatment of locally advanced or metastatic cutaneous squamous cell carcinoma -- 7 Concluding remarks -- 12 OSTEOSARCOMA METASTASIS-PROGNOSTIC FACTORS AND TREATMENT STRATEGIES -- 1 Introduction -- 2 Clinical features of metastasis from osteosarcoma -- 3 Treatment for metastasis from osteosarcoma -- 4 Conclusion -- II CANCER METASTASIS TO DISTANT ORGANS -- 13 LYMPH NODE METASTASIS -- 1 Introduction -- 2 History -- 3 Mechanisms-how tumors metastasize to lymph nodes -- 4 Clinical aspects of lymph node metastasis -- 5 Pathology -- 6 Conclusions and summary -- 14 MOLECULAR INVOLVEMENT OF THE BONE MARROW MICROENVIRONMENT IN BONE METASTASIS -- 1 Introduction -- 2 Types of bone metastasis -- 3 Pathophysiology of bone metastasis -- 4 Treatment options for bone metastasis -- 5 Discussion/conclusion -- 15 AN OVERVIEW ON HEPATIC METASTASIS -- 1 Introduction -- 2 Hepatic physiology and cancer biology -- 3 Hepatic functional and surgical anatomy -- 4 Clinical presentation and diagnosis -- 5 Treatment of hepatic metastasis -- 6 Conclusions -- 16 PULMONARY METASTASIS -- 1 Development of pulmonary metastasis -- 2 Rationale for local treatment of pulmonary metastases -- 3 Diagnosis of pulmonary metastases -- 4 Preoperative exams -- 5 Surgical resection -- 6 Radiological ablation -- 7 Radiotherapy -- 8 Lymph node involvement -- 9 Resection of recurrent metastases -- 10 Lung metastasis in given tumor types -- 11 Conclusion -- 17 BRAIN METASTASIS: BASIC BIOLOGY, CLINICAL MANAGEMENT, AND INSIGHT FROM EXPERIMENTAL MODEL SYSTEMS -- 1 Introduction -- 2 Biology -- 3 Clinical management -- 4 Experimental model systems -- 5 Preclinical findings -- 6 Conclusions -- III EMERGING TARGETS FOR CANCER METASTASIS -- 18 DEVELOPMENTAL PATHWAYS: EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS -- 1 Introduction -- 2 Prometastatic changes and developmental pathways -- 3 Notch signaling and metastasis -- 4 Antimetastatic potential of Wnt and hedgehog targeting -- 5 Concluding remarks -- 19 EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS: FROM THE PERSPECTIVE OF EMBRYO IMPLANTATION -- 1 Introduction -- 2 The similarity between embryo implantation and tumor metastasis -- 3 Trophoblast invasion inhibitory factors derived from the maternal endometrium during embryo implantation and their implications in cancer metastasis -- 4 Conclusions and perspectives -- 20 WNT SIGNALING AS A THERAPEUTIC TARGET IN CANCER AND METASTASIS -- 1 Introduction -- 2 Wnt signaling and cancer -- 3 The role of Wnt signaling in epithelial-mesenchymal transition and cancer stem cells -- 4 Therapeutic strategies targeting Wnt signaling -- 5 Protein knockdown strategies -- 6 Viral-based therapies -- 7 Conclusion .
Subject: "Introduction to Cancer Metastasis provides an overview of cancer metastais and novel therapeutic targets, all in one place. Through specific chapters on three divers topics - primary cancers and their metastasis, common metastatic sites and emerging targets for therapy - this volume comprehensively informs readers on the broader knowledge gained on cancer metastasis so far. Key features: Includes basic biology and translational approaches to organ-specific cancer sites; Provides readers with information on emerging therapeutic targets for cancer metastasis; Contains contributions from leading researchers around the globe"--P. [4] of cover.
Tags from this library: No tags from this library for this title. Log in to add tags.
Holdings
Item type Current library Call number Status Date due Barcode
Books Books KMTC:NAIROBI CAMPUS General Stacks RC269.5.I58 2017 (Browse shelf(Opens below)) Available 31349

Includes bibliographical references and index.

List of contributors --
Preface --
I CANCER METASTASIS FROM PRIMARY ORGANS --
1 CANCER METASTASIS: AN INTRODUCTION --
1. Introduction --
2. Disruption of Cell Adhesion: Initiation of Metastasis --
3. Matrix Metalloproteinases in Cancer Metastasis --
4. EMT in Cancer Metastasis --
5. Organ-Specific Metastasis --
6. microRNAs and Cancer Stem Cells in Cancer Metastasis --
7. Conclusions and Perspectives --
2. BREAST CANCER METASTASIS --
1. Introduction --
2. Biology --
3. Metastatic Dissemination --
4. Prognostic Factors After Recurrence --
5. Treatment for Metastatic Breast Cancer --
6. Conclusions --
3. PROSTATE CANCER METASTASIS -
1. Epidemiology and Overview of Metastatic Prostate Cancer --
2. Cellular Biology of Prostate Cancer Metastases --
3. The Metastatic Cascade --
4. Conclusions --
4. LUNG CANCER METASTASIS --
1. General Information --
2. Mechanism of Metastasis --
3. Molecular Mechanism in the Regulation of Lung Cancer Metastasis --
4. Epithelial to Mesenchymal Transition in Lung Cancer --
5. Cancer Stem Cells -- 6. Concluding Remarks --
5. CERVICAL CANCER METASTASIS --
1. Introduction --
2. Risk Factors --
3. Pathogenesis --
4. Histopathology --
5. Routes of Dissemination --
6. Major Molecular Factors --
7. Conclusion --
6. COLORECTAL CANCER METASTASIS --
1. Introduction --
2. Molecular Aspects of Colorectal Cancer Metastasis --
3. Main Sites of Colorectal Cancer Metastasis --
4. Therapeutic Options for Metastatic Colorectal Cancer --
5. Challenges and Probable Solutions --
6. Conclusions --
7. METASTATIC PANCREATIC CANCER: CURRENT STATE AND FUTURE DIRECTIONS --
1 Introduction --
2 Management of pancreatic ductal adenocarcinoma --
3 Molecular mechanisms driving metastasis --
4 In vivo experimental models --
5 Open question: onset and dynamics of metastasis --
6 Conclusions --
8 GASTRIC CANCER METASTASIS --
1 Epidemiology and screening programs --
2 Metastatic GC -- clinical aspects --
3 Diagnosis of metastatic GC with a particular focus on 18-F-FDG PET/CT -- 4
Prognostic and predictive factors --
5 Biomarkers --
6 Treatment methods of metastatic GC --
7 Conclusion --
9 HEPATOCELLULAR CARCINOMA: METASTATIC DISEASE --
1 Introduction --
2 Epidemiology --
3 Diagnosis --
4 Prognosis and staging --
5 Treatment --
6 Conclusions --
10 METASTATIC BLADDER CANCER --
1 Introduction --
2 Epidemiology --
3 Staging --
4 Grading --
5 Staging tools --
6 Emerging biomarkers --
7 Prognostic factors --
8 Clinical presentation of metastatic bladder disease --
9 Management of clinically localized bladder cancer, positive pelvic nodes and metastatic disease --
10 Clinical prognosticators --
11 Management of metastatic bladder cancer --
12 New agents --
13 Immunotherapy --
14 Role of surgery in metastatic bladder cancer --
15 Conclusions --
11 METASTATIC CUTANEOUS SQUAMOUS CELL CARCINOMAS --
1 Introduction --
2 Defining the high-risk variant --
3 Staging systems --
4 Treating high-risk cutaneous squamous cell carcinoma --
5 Sentinel node biopsy --
6 Treatment of locally advanced or metastatic cutaneous squamous cell carcinoma --
7 Concluding remarks --
12 OSTEOSARCOMA METASTASIS-PROGNOSTIC FACTORS AND TREATMENT STRATEGIES --
1 Introduction --
2 Clinical features of metastasis from osteosarcoma --
3 Treatment for metastasis from osteosarcoma --
4 Conclusion --
II CANCER METASTASIS TO DISTANT ORGANS --
13 LYMPH NODE METASTASIS --
1 Introduction --
2 History --
3 Mechanisms-how tumors metastasize to lymph nodes --
4 Clinical aspects of lymph node metastasis --
5 Pathology --
6 Conclusions and summary --
14 MOLECULAR INVOLVEMENT OF THE BONE MARROW MICROENVIRONMENT IN BONE METASTASIS --
1 Introduction --
2 Types of bone metastasis --
3 Pathophysiology of bone metastasis --
4 Treatment options for bone metastasis --
5 Discussion/conclusion --
15 AN OVERVIEW ON HEPATIC METASTASIS --
1 Introduction --
2 Hepatic physiology and cancer biology --
3 Hepatic functional and surgical anatomy --
4 Clinical presentation and diagnosis --
5 Treatment of hepatic metastasis --
6 Conclusions --
16 PULMONARY METASTASIS --
1 Development of pulmonary metastasis --
2 Rationale for local treatment of pulmonary metastases --
3 Diagnosis of pulmonary metastases --
4 Preoperative exams --
5 Surgical resection --
6 Radiological ablation --
7 Radiotherapy --
8 Lymph node involvement --
9 Resection of recurrent metastases --
10 Lung metastasis in given tumor types --
11 Conclusion --
17 BRAIN METASTASIS: BASIC BIOLOGY, CLINICAL MANAGEMENT, AND INSIGHT FROM EXPERIMENTAL MODEL SYSTEMS --
1 Introduction --
2 Biology --
3 Clinical management --
4 Experimental model systems --
5 Preclinical findings --
6 Conclusions --
III EMERGING TARGETS FOR CANCER METASTASIS --
18 DEVELOPMENTAL PATHWAYS: EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS --
1 Introduction --
2 Prometastatic changes and developmental pathways --
3 Notch signaling and metastasis --
4 Antimetastatic potential of Wnt and hedgehog targeting --
5 Concluding remarks --
19 EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS: FROM THE PERSPECTIVE OF EMBRYO IMPLANTATION --
1 Introduction --
2 The similarity between embryo implantation and tumor metastasis --
3 Trophoblast invasion inhibitory factors derived from the maternal endometrium during embryo implantation and their implications in cancer metastasis --
4 Conclusions and perspectives --
20 WNT SIGNALING AS A THERAPEUTIC TARGET IN CANCER AND METASTASIS --
1 Introduction --
2 Wnt signaling and cancer --
3 The role of Wnt signaling in epithelial-mesenchymal transition and cancer stem cells --
4 Therapeutic strategies targeting Wnt signaling --
5 Protein knockdown strategies --
6 Viral-based therapies --
7 Conclusion .

"Introduction to Cancer Metastasis provides an overview of cancer metastais and novel therapeutic targets, all in one place. Through specific chapters on three divers topics - primary cancers and their metastasis, common metastatic sites and emerging targets for therapy - this volume comprehensively informs readers on the broader knowledge gained on cancer metastasis so far. Key features: Includes basic biology and translational approaches to organ-specific cancer sites; Provides readers with information on emerging therapeutic targets for cancer metastasis; Contains contributions from leading researchers around the globe"--P. [4] of cover.

There are no comments on this title.

to post a comment.

© 2024, Kenya Medical Training College | All Rights Reserved