TY - BOOK AU - Laurence D.R AU - Bennett,P.N AU - Brown,M.J. TI - Clinical pharmacology SN - 0443049904 AV - RM301.28 .L38 1997 PY - 1997/// CY - Edinburgh PB - Churchill Livingstone KW - pharmacology N1 - includes bibliographical references and index; Preface vii (2) Acknowledgements ix (1) Note from the authors and publishers x Section 1 GENERAL 3 (74) 1. Topics in drug therapy 3 (34) 2. Clinical pharmacology 37 (3) 3. Discovery and development of drugs 40 (7) 4. Evaluation of drugs in man 47 (17) 5. Official regulation of medicines 64 (7) 6. Classification and naming of drugs 71 (6) Section 2 FROM PHARMACOLOGY TO TOXICOLOGY 77 (110) 7. General pharmacology 77 (44) 8. Unwanted effects and adverse drug reactions 121 (17) 9. Poisoning, overdose, antidotes 138 (13) 10. Nonmedical use of drugs 151 (36) Section 3 INFECTION AND INFLAMMATION 187 (98) 11. Chemotherapy of infections 187 (10) 12. Antibacterial drugs 197 (18) 13. Chemotherapy of bacterial infections 215 (16) 14. Viral, fungal, protozoal and helminthic infections 231 (18) 15. Inflammation, arthritis and nonsteroidal anti-inflammatory drugs (NSAIDs) 249 (18) 16. Drugs and the skin 267 (18) Section 4 NERVOUS SYSTEM 285 (114) 17. Pain and analgesics 285 (25) 18. Sleep and anxiety 310 (17) 19. Drugs and mental disorder 327 (29) 20. Epilepsy, parkinsonism and allied conditions 356 (17) 21. Anaesthesia and neuromuscular block 373 (26) Section 5 CARDIORESPIRATORY AND RENAL SYSTEMS 399 (120) 22. Cholinergic and antimuscarinic (anticholinergic) drugs 399 (13) 23. Adrenergic mechanisms (sympathomimetics, shock, hypotension) 412 (13) 24. Arterial hypertension, angina pectoris, myocardial infarction 425 (33) 25. Cardiac dysrhythmia and failure 458 (20) 26. Hyperlipidaemias 478 (6) 27. Kidney and urinary tract 484 (16) 28. Respiratory system 500 (19) Section 6 BLOOD AND NEOPLASTIC DISEASE 519 (48) 29. Drugs and haemostasis 519 (15) 30. Cellular disorders and anaemias 534 (11) 31. Neoplastic disease and immunosuppression 545 (22) Section 7 GASTROINTESTINAL SYSTEM 567 (32) 32. Stomach and oesophagus 567 (12) 33. Intestines 579 (10) 34. Liver, biliary tract, pancreas 589 (10) Section 8 ENDOCRINE SYSTEM, METABOLIC CONDITIONS 599 (77) 35. Adrenal corticosteroids, antagonists, corticotrophin 599 (16) 36. Diabetes mellitus, insulin, oral antidiabetes agents 615 (18) 37. Thyroid hormones, antithyroid drugs 633 (9) 38. Hypothalamic, pituitary and sex hormones 642 (25) 39. Vitamins, calcium, bone 667 (9) Index 676 N2 - This book is about the rational scientific basis and practice of drug therapy. Doctors need to understand the psychological and medical area in which they prescribe to deliver what patients have a right to expect, ie. maximum benefit with minimum risk ER -