Physical pharmacy/ David. Attwood; Alexander T. Florence

Includes index.

Machine generated contents note: 1.Solids
Crystal structure and external appearance
Polymorphism
Crystal hydrates
Co-crystals
Amorphous solids
Importance of particle size
Wetting of solid surfaces and powders
Dissolution of drugs
Sublimation and freeze drying
Solid solutions and dispersions
Multiple choice questions
Memory maps
2.Solubility and solution properties of drugs
Concentration units
Solvents for pharmaceutical aerosois
Factors influencing solubility
Ionisation of drugs in solution
pH of drug solutions
Buffers
Thermodynamic properties of drugs in solution
Osmotic properties of drugs in solution
isotonic solutions
Partitioning of drugs between immiscible solvents
Diffusion of drugs in solution
Multiple choice questions
Memory maps
3.Drug stability
The chemical breakdown of drugs
Kinetics of chemical decomposition in solution
Factors influencing drug stability of liquid dosage forms Note continued: Factors influencing drug stability of solid dosage forms
Stability testing and calculation of shelf-life
Multiple choice questions
Memory maps
4.Surfactants
Types of surfactant
Some typical surfactants
Reduction of surface and interfacial tension
Insoluble monolayers
Lung surfactant monolayers
Adsorption at the solid-liquid interface
Micellisation
Formation of liquid crystals and vesicles
Solubilisation
Multiple choice questions
Memory maps
5.Emulsions, suspensions and other dispersed systems
Colloid stability
Emulsions
Suspensions
Foams and defoamers
Multiple choice questions
Memory maps
6.Polymers
Polymer structure
Solution properties of polymers
Properties of polymer gels
Some water-soluble polymers used in pharmacy and medicine
Water-insoluble polymers
Application of polymers in drug delivery
Multiple choice questions
Memory maps
7.Drug absorption Note continued: Biological membranes and drug transport
Routes of administration
The oral route and oral absorption
Buccal and sublingual absorption
Intravenous injection and infusion
Intramuscular and subcutaneous injection
Transdermal delivery
The eye
The ear
Absorption from the vagina
Inhalation therapy
Physical factors affecting deposition of aerosols
The nasal route
Rectal absorption of drugs
Intrathecal drug administration
Multiple choice questions
Memory maps
8.Physicochemical drug Interactions and Incompatibilities
Solubility problems
pH effects in vitro and in vivo
Dilution of mixed solvent systems
Cation-anlon interactions
Ion-pair formation
Chelation and other forms of complexation
Adsorption of drugs
Drug interactions with plastics
Protein binding of drugs
Multiple choice questions
Memory maps
9.Peptides, proteins and other biopharmaceuticals Note continued: Structure and solution properties of peptides and proteins
The stability of proteins and peptides
Protein formulation and delivery
Therapeutic proteins and peptides
DNA and oligonucleotides
Monoclonal antibodies
Multiple choice questions
Memory maps
10.In vitro assessment of dosage forms
Dissolution testing of solid dosage forms
In vitro evaluation of non-oral systems
Rheological characteristics of products
Adhesivity of dosage forms
Particle size distribution in aerosols
In vitro-in vivo correlations
Multiple choice questions
Memory maps
11.Pharmaceutical nanotechnology
Introduction
Particle size
Physicochemical characterisation of nanosystems
Nanoparticles as drug carriers
Nanoparticle manufacturing methods
Drug targeting with nanoparticles and particle flow
Aggregation and PEGylation
Nanoparticle diffusion
Conclusions
Multiple choice questions
Memory maps