TY - BOOK AU - Wedzicha,Jadwiga Anna AU - Martinez,Fernando J. TI - Chronic obstructive pulmonary disease exacerbations SN - 9781420070866 AV - RC776.O3.C47 2009 PY - 2009/// CY - New York PB - Informa Healthcare KW - Lungs KW - Diseases, Obstructive KW - Complications KW - Pulmonary Disease, Chronic Obstructive KW - Recurrence N1 - Includes bibliographical references and index; CONTENTS Part I: Introduction. 1. Definitions and severity of COPD exacerbations -- 2. Epidemiology of COPD exacerbations -- 3. Differential diagnosis of COPD exacerbations -- PART II: Mechanisms and Pathophysiology. 4. Symptom changes at exacerbations -- 5. Airway pathology at exacerbations -- 6. Airway and systemic inflammatory markers at exacerbation -- 7. Pathophysiology of acute exacerbations of COPD -- 8. Systemic consequences of COPD exacerbations -- 9. Mechanisms of respiratory failure at exacerbations -- 10. Role of respiratory viral infection at exacerbation -- 11. Do airway bacteria cause COPD exacerbations? -- 12. Interactions of airway pathogens and inflammatory processes -- 13. Role of co-morbidity at COPD exacerbations -- 14. Environmental causes of exacerbations -- 15. Mechanisms and pathophysiological changes in alpha-1 AT deficiency exacerbations -- 16. Animal models of COPD exacerbations -- 17. Comparison of asthma and COPD exacerbations -- Part III: Impact of Exacerbations. 18. Risk factors for hospital admission -- 19. Effect of exacerbations on disease progression and mortality -- 20. Health economic consequences of COPD exacerbations -- Part IV: Management of the Acute Exacerbation. 21. Use of bronchodilators and mucolytics at COPD exacerbations -- 22. Corticosteroids in the management of acute exacerbations -- 23. Antibiotic therapy at COPD exacerbations -- 24. Non invasive ventilatory support in acute exacerbations of COPD -- 25. Invasive ventilation and weaning at COPD exacerbation -- 26. Oxygen therapy at exacerbations -- 27. End of life issues and COPD exacerbations -- 28. Novel models of care for COPD exacerbations -- 29. Physiotherapy airway clearance at exacerbation -- 30. COPD exacerbation and pulmonary rehabilitation -- Part V: Prevention of COPD Exacerbation. 31. Pharmacological prevention of COPD exacerbations -- 32. Early intervention and self-management in exacerbation prevention -- 33. Immunological interventions -- 34. Home mechanical ventilation and oxygen therapy -- Part VI: Issues for Studies of COPD Exacerbations. 35. Design of trials for COPD exacerbations -- 36. Statistical considerations for COPD exacerbation trials -- 37. Future development in COPD exacerbations N2 - Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations. Written by today 's top experts, Chronic Obstructive Pulmonary Disease Exacerbations -- is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-useexamines current and breakthrough pharmacologic and non-pharmacologic treatmentsincludes COPD-causing exacerbations such as viral and bacterial infectionsdiscusses the negative environmental factors relating to COPD UR - http://www.loc.gov/catdir/toc/ecip0818/2008021270.html ER -