000			02746nam a22003137a 4500
003			KENaKMTC
005			20260520102226.0
008			260520b |||||||| |||| 00| 0 eng d
020			_a9780781782104
040			_cDLC
050	0	0	_aR853.C55 _bD47 2007
100			_aHulley B. Stephen
245	0	0	_aDesigning clinical research / _cStephen B. Hulley ... [et al.].
250			_a3rd ed.
260			_aPhiladelphia, PA : _bLippincott Williams & Wilkins, _cc2007.
300			_axv, 367 p. ill. ; _c26 cm.
440			_aDesigning Clinical Research
504			_aIncludes bibliographical references and index.
505	0		_aGetting started: the anatomy and physiology of clinical research / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Conceiving the research question / Steven R. Cummings, Warren S. Browner, and Stephen B. Hulley -- Choosing the study subjects: specification, sampling, and recruitment / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Planning the measurements: precision and accuracy / Stephen B. Hulley and Steven R. Cummings -- Getting ready to estimate sample size: hypotheses and underlying principles / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Estimating sample size and power: applications and examples / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Designing an observational study: cohort studies / Steven R. Cummings, Thomas B. Newman, and Stephen B. Hulley -- Designing an observational study: cross-sectional and case-control studies / Thomas B. Newman ... [et al.] -- Enhancing causal inference in observational studies / Thomas B. Newman, Warren S. Browner, and Stephen B. Hulley --
505	0		_aDesigning a randomized blinded trial / Steven R. Cummings, Deborah Grady, and Stephen B. Hulley -- Alternative trial designs and implementation issues / Deborah Grady, Steven R. Cummings, and Stephen B. Hulley -- Designing studies of medical tests / Thomas B. Newman, Warren S. Browner, and Steven R. Cummings -- Research using existing databases: secondary data analysis, ancillary studies, and systematic reviews / Deborah Grady and Norman Hearst -- Addressing ethical issues / Bernard Lo -- Designing questionnaires and interviews / Steven R. Cummings and Stephen B. Hulley -- Data management / Michael A. Kohn -- Implementing the study: pretesting, quality control, and protocol revisions / Stephen B. Hulley and Steven R. Cummings.
650		0	_aClinical trials.
650		0	_aMedicine _xResearch _xMethodology.
650		0	_aEpidemiology _xResearch _xMethodology.
650	1	2	_aEpidemiologic Methods.
650	2	2	_aResearch Design.
700	1		_aHulley, Stephen B.
856	4	1	_uTable of contents only
942			_2lcc _cBK _xFN
999			_c60469 _d60469