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Principles of Tissue Engineering Robert Lanza,Robert Langer,Joseph P.Vacanti and Anthony Atala

Contributor(s): Material type: TextTextPublication details: London, United Kingdom; Academic Press, c2020.Edition: 5th EditionDescription: xli,1635p.: col ill.; 28cmISBN:
  • 9780128184226
Subject(s): LOC classification:
  • R857.T55 .P75 2020
Contents:
Front Cover Principles of Tissue Engineering Copyright Page Contents List of contributors Preface 1 Tissue engineering: current status and future perspectives Clinical need Current state of the field Smart biomaterials Cell sources Embryonic stem cells Induced pluripotent stem cells Adult stem cells Whole organ engineering Biofabrication technologies Electrospinning Inkjet three-dimensional bioprinting Extrusion three-dimensional bioprinting Spheroids and organoids Imaging technologies Tissue neovascularization Bioreactors Organ-on-a-chip and body-on-a-chip Integration of nanotechnology Current challenges Future directions Smart biomaterials Cell sources Embryonic stem cells Induced pluripotent stem cells Adult stem cells Whole organ engineering Biofabrication technologies Tissue neovasculatization Bioreactors Integration of nanotechnology Conclusions and future challenges References Further reading 2 From mathematical modeling and machine learning to clinical reality Introduction Modeling stem cell dynamics Positive feedback-based molecular switches Variability in stem cell populations Modeling tissue growth and development Monolayer tissue growth in vitro Tissue growth on complex surfaces in vitro Three-dimensional tissue growth in vitro Pattern formation Machine learning in tissue engineering Supervised methods Unsupervised methods Machine learning of cellular dynamics Regulatory network inference From mathematical models to clinical reality References 3 Moving into the clinic Introduction Current state of tissue engineering Pathway for clinical translation Regulatory considerations for tissue engineering Conclusion Acknowledgment References Further reading One: The basis of growth and differentiation 4 Molecular biology of the cell The cell nucleus Control of gene expression Transcription factors Other controls of gene activity The cytoplasm The cytoskeleton Microtubules Microfilaments Small GTPases The cell surface Cell adhesion molecules Extracellular matrix Signal transduction Growth and death Culture media Cells in tissues and organs Cell types Tissues Organs Reference Further reading General Chromatin Signaling, general Cytoskeleton, adhesion molecules and extracellular matrix 5 Molecular organization of cells Introduction Molecules that organize cells Changes in cell-cell adhesion Changes in celleextracellular matrix adhesion Changes in cell polarity and stimulation of cell motility Invasion of the basal lamina The epithelial-mesenchymal transition transcriptional program Transcription factors that regulate epithelial-mesenchymal transition Regulation at the promoter level
Summary: This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field
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Item type Current library Call number Status Date due Barcode
Books Books KMTC:KISUMU CAMPUS General Stacks R857.T55 .P75 2020 (Browse shelf(Opens below)) Available KSM/12916

Includes Bibliographical references and Index


Front Cover
Principles of Tissue Engineering
Copyright Page
Contents
List of contributors
Preface
1 Tissue engineering: current status and future perspectives
Clinical need
Current state of the field
Smart biomaterials
Cell sources
Embryonic stem cells
Induced pluripotent stem cells
Adult stem cells
Whole organ engineering
Biofabrication technologies
Electrospinning
Inkjet three-dimensional bioprinting
Extrusion three-dimensional bioprinting
Spheroids and organoids
Imaging technologies
Tissue neovascularization
Bioreactors Organ-on-a-chip and body-on-a-chip
Integration of nanotechnology
Current challenges
Future directions
Smart biomaterials
Cell sources
Embryonic stem cells
Induced pluripotent stem cells
Adult stem cells
Whole organ engineering
Biofabrication technologies
Tissue neovasculatization
Bioreactors
Integration of nanotechnology
Conclusions and future challenges
References
Further reading
2 From mathematical modeling and machine learning to clinical reality
Introduction
Modeling stem cell dynamics
Positive feedback-based molecular switches Variability in stem cell populations
Modeling tissue growth and development
Monolayer tissue growth in vitro
Tissue growth on complex surfaces in vitro
Three-dimensional tissue growth in vitro
Pattern formation
Machine learning in tissue engineering
Supervised methods
Unsupervised methods
Machine learning of cellular dynamics
Regulatory network inference
From mathematical models to clinical reality
References
3 Moving into the clinic
Introduction
Current state of tissue engineering
Pathway for clinical translation Regulatory considerations for tissue engineering
Conclusion
Acknowledgment
References
Further reading
One: The basis of growth and differentiation
4 Molecular biology of the cell
The cell nucleus
Control of gene expression
Transcription factors
Other controls of gene activity
The cytoplasm
The cytoskeleton
Microtubules
Microfilaments
Small GTPases
The cell surface
Cell adhesion molecules
Extracellular matrix
Signal transduction
Growth and death
Culture media
Cells in tissues and organs
Cell types
Tissues
Organs Reference
Further reading
General
Chromatin
Signaling, general
Cytoskeleton, adhesion molecules and extracellular matrix
5 Molecular organization of cells
Introduction
Molecules that organize cells
Changes in cell-cell adhesion
Changes in celleextracellular matrix adhesion
Changes in cell polarity and stimulation of cell motility
Invasion of the basal lamina
The epithelial-mesenchymal transition transcriptional program
Transcription factors that regulate epithelial-mesenchymal transition
Regulation at the promoter level

This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field

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